Novirax 5% Cream | 5gm Tube | ePharma
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Novirax 5% Cream 5gm

Generic: Acyclovir

Type: Cream

Pack Size: 1s pack

Novirax cream is indicated for the treatment of recurrent herpes labialis (cold sores) in immunocompetent adults and adolescents 12 years of age and older.


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Discount Price: ৳ 45.12
MRP: ৳ 48 6% Off

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✅ Description:

1. Herpes Zoster (Shingles):

  • A viral infection causing a painful rash, characterized by red skin rashes, pain, and burning. The virus (Varicella-Zoster virus) remains dormant in the nervous system for years before reactivating as shingles. It typically appears on the face, neck, torso, and one side of the body, and can also affect the eyes (ophthalmic herpes zoster).
  • Antiviral medicines like Acyclovir help in managing shingles by reducing pain and speeding up the healing process.

2. Genital Herpes Infection:

  • A common sexually transmitted infection affecting both men and women is characterized by genital pain, irritation, itching, and sores. It is marked by genital pain and sores.
  • Acyclovir helps alleviate the symptoms and promotes the healing of sores in genital herpes.

3. Herpes Labialis:

  • A viral infection affecting the lips is commonly known as cold sores. Symptoms include burning pain and small blisters on the lips. In some cases, it can also cause fever.
  • Acyclovir aids in the healing process of cold sores, reducing pain and speeding up recovery.

4. Chickenpox:

  • A highly contagious viral infection presenting with a rash, small painful blisters, fever, sore throat, and body pain.
  • Acyclovir tablets should be taken within 24 to 48 hours after the onset of chickenpox rash to aid in recovery. It is important to avoid contact with others who have chickenpox and maintain good hygiene to prevent the spread of the virus.

Safety Advices


Alcohol
UNSAFE

Limit alcohol intake while using Acyclovir to prevent any adverse effects.


Pregnancy
CONSULT YOUR DOCTOR

Acyclovir is a pregnancy Category B medicine. It is not known whether Acyclovir will affect pregnant women or the fetus. Hence, the intake of Acyclovir should be only if prescribed and under medical supervision.


Breastfeeding
CONSULT YOUR DOCTOR

Acyclovir is a pregnancy Category B medicine. It is not known whether Acyclovir will pass through the milk in breastfeeding women. Hence, Acyclovir should only be taken if prescribed by a doctor and under medical supervision.


Driving
CAUTION

No interaction found/established


Kidney
CAUTION

Acyclovir should be taken with caution, especially if you have a history of kidney diseases or conditions. The dose may have to be adjusted by your doctor.


Liver
SAFE IF PRESCRIBED

Acyclovir is safe if prescribed by a doctor. It is known not to interact with liver functioning.

Similar Products

✔️ Uses of Acyclovir
  • Genital Herpes
  • Herpes labialis
✔️ How does Acyclovir work?

Acyclovir works by inhibiting the multiplication of the virus and thereby reducing the severity of the infection.

✔️ Side Effects of Acyclovir

Common adverse reactions at the application site include dry lips, desquamation, dryness of skin, cracked lips, burning skin, pruritus, flakiness of skin, and stinging. These occurred in less than 1% of patients. Discontinuation due to adverse events occurred in three patients on Novirax cream and one patient on placebo.

✔️ Quick Suggestions:
  • Acyclovir helps in the treatment of herpes, chickenpox, and shingles.
  • Do not skip any doses and finish the full course of treatment even if you feel better.
  • Drink plenty of water while on treatment with this medicine. This helps to prevent dehydration and kidney damage.
  • If you have genital herpes, use barrier methods (condoms) for contraception and avoid sexual contact while the sores are present.
  • Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
✔️ Indication of Acyclovir

Novirax cream is a topical antiviral medication designed to treat recurrent herpes labialis. With a well-established pharmacological profile, it provides targeted relief by inhibiting viral DNA replication. Suitable for use in both adults and adolescents over 12 years of age, it should be applied five times daily for optimal results. The product is safe with minimal side effects and no significant drug interactions.

✔️ Pharmacology

Acyclovir, the active ingredient in Novirax cream, is an antiviral drug effective against herpes simplex virus (HSV). It is a synthetic purine nucleoside analog with inhibitory activity against HSV types 1 (HSV-1) and 2 (HSV-2). Acyclovir's action is highly selective due to its affinity for the HSV-encoded enzyme thymidine kinase (TK), which converts acyclovir into acyclovir monophosphate, then to diphosphate by cellular guanylate kinase, and finally to triphosphate by various cellular enzymes. Acyclovir triphosphate inhibits herpes viral DNA replication through:

  1. Competitive inhibition of viral DNA polymerase.
  2. Incorporation into and termination of the growing viral DNA chain.
  3. Inactivation of the viral DNA polymerase.
✔️ Dosage & Administration of Acyclovir
  • Adults and Adolescents (12 years and older): Apply acyclovir cream five times daily for four days.
  • Initiation of Therapy: Begin as early as possible following the onset of herpes labialis signs or symptoms (during the prodrome or when lesions appear).
  • Pediatric Use: Safety and effectiveness in patients under 12 years have not been established. In patients aged 12-17, the safety profile was similar to adults.
  • Geriatric Use: Insufficient data to determine differences in response compared to younger subjects. Minimal systemic absorption suggests no significant differences.
✔️ Drug Interactions for Acyclovir

1. Drug-Drug Interaction:

  • Probenecid: Used to treat gout, can increase blood levels of  Acyclovir.
  • Cimetidine: Used to treat stomach ulcers, may increase  Acyclovir blood levels.
  • Mycophenolate Mofetil: Used to prevent organ rejection, can affect  Acyclovir blood levels.
  • Aminophylline and Theophylline: Used to treat asthma, may interact with  Acyclovir and affect its effectiveness or increase side effects.

2. Drug-Food Interaction:

  • Non-Prescription Medications, Vitamins, Nutritional Supplements, and Herbal Products:  Acyclovir may interact with various over-the-counter medications, vitamins, supplements, and herbal products you are taking or plan to take, potentially affecting its effectiveness or increasing side effects. Always consult with your doctor before combining  Acyclovir with other substances.

3. Drug-Disease Interaction:

  • Renal Dysfunction or Disease:  Acyclovir can affect kidney function, so inform your doctor if you have any kidney-related issues.
  • Hemodialysis: Patients undergoing hemodialysis may require dose adjustments as the procedure can alter  Acyclovir levels.
  • Organ Transplant: Inform your doctor if you have had an organ transplant as it may affect  Acyclovir use and dosage.
  • Immunodeficiency: Individuals with weakened immune systems need to be cautious as  Acyclovir may have specific considerations in such conditions.
  • Bone Marrow Transplantation: This condition may affect  Acyclovir's use and effectiveness.
  • Neutropenia: Lower-than-normal levels of neutrophils can influence the use of  Acyclovir and require careful monitoring and possible dose adjustments.
✔️ Contraindications

Novirax cream is contraindicated in patients with known hypersensitivity to acyclovir, valacyclovir, or any component of the formulation.

✔️ Pregnancy & Lactation
  • Pregnancy: Category B. Use only if the potential benefit justifies the potential risk to the fetus.
  • Lactation: It is unknown if topically applied acyclovir is excreted in breast milk. Systemic exposure from topical administration is minimal.
✔️ Precautions & Warnings
  • Apply only to the affected external aspects of the lips and face.
  • Avoid application to human mucous membranes.
  • For cutaneous use only; avoid use in the eye or inside the mouth or nose.
  • Potential for irritation and contact sensitivity.
  • Effectiveness in immunocompromised patients has not been established.
✔️ Storage Conditions:

Store Novirax cream at room temperature between 20°C to 25°C.

Frequently Asked Questions (FAQ)

No, you can infect other people, even while you are being treated with Novirax 5% Cream. Herpes infections are contagious, so avoid letting infected areas come into contact with other people. Avoid touching your eyes after touching an infected area. Wash your hands frequently to prevent transmitting the infection to others. You should practice safe sex by using condoms. You should not have sex if you have genital sores or blisters.

Older adults (over age 65 years) tend to experience more side effects when taking Acyclovir. The reason is, that their kidneys do not flush the drug out of their system as quickly as a younger person’s kidneys would do. Elderly patients should drink plenty of water while taking Acyclovir, and their kidney function should be monitored. These patients should be given a lower dose and should be monitored for neurological problems.

Hair loss is an uncommon side effect of Acyclovir. It stops when the medicine is discontinued.

Novirax 5% Cream is an antiviral medicine effective against herpes simplex and varicella zoster viruses. It does not cure infections caused by these viruses but helps to minimize the symptoms and shorten the duration of infection. It does not remove the viruses from the body but prevents the viruses from dividing and spreading.

Serious side effects are rare, but if you experience them, you should seek medical advice right away. These rare side effects include hives, blistering or peeling rash, yellow skin or eyes, unusual bruising or bleeding, loss of consciousness, fits, difficulty in breathing, hallucinations, and swelling of the face, tongue, lips, or throat.

Patients with advanced HIV disease or patients with impaired immunity have reported resistance to Acyclovir. If you are not responding to Acyclovir, the possibility of drug resistance should be checked.

Accidental, repeated overdoses of oral Acyclovir over several days have resulted in nausea, vomiting, confusion, and headache. Consult your doctor in case of an overdose.
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Check our pricing section for Novirax 5% Cream 5gm price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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